Last weekend i was in Leiden, a short train trip away from Amsterdam, for the opening of an exhibition of the winning projects of the third edition of the Designers & Artists 4 Genomics Award.
The DA4GA give artists the opportunity to develop ambitious projects in cooperation with life science institutions carrying out research into the genetic makeup of people, animals, plants and microorganisms.
One of the recipients of the award is Charlotte Jarvis who used her own body to demystify the processes and challenge the prejudices and misunderstandings that surround stem cell technology.
Ergo Sum started as a performance at the WAAG Society in Amsterdam. In front of the public, the artist donated parts of her body to stem cell research. Blood, skin and urine samples were taken and sent to the stem cell research laboratory at The Leiden University Medical Centre iPSC Core Facility headed by Prof. Dr. Christine Mummery.
The scientists then transformed the samples into induced pluripotent stem cells, which in turn have been programmed to grow into cells with different functions such as heart, brain and vascular cells.
The whole process used the innovation which earned John Gurdon and Shinya Yamanaka a joint Nobel Prize last year. The two scientists are indeed behind the discovery that adult, specialised cells can be reprogrammed and turned back into embryo-like stem cells that can become virtually any cell type and thus develop into any tissue of the body.
The pluripotent stem cells offer an alternative to using embryonic stem cells, removing the ethical questions and controversies that surrounded the use of embryonic stem cells.
But let's get back to Charlotte's stem cells. Copies are now kept by the university for scientists to use in their research. And because the cells can be stored for an unlimited period, they are immortal. The ones that are on view at the exhibition in Leiden right now have to be kept alive by a team of scientists who regularly visit the exhibition space to care for the cells.
The synthesized body parts (now brain, heart and blood cells) are kept in an incubator made especially by a company specialized in museum displays as traditional incubator don't have a window that would allow the public to have a peak inside. The cells are accompanied by videos, prints of email exchanges, photos and other items that document the whole story of the project.
Ergo Sum is a biological self-portrait; a second self; biologically and genetically 'Charlotte' although also 'alien' to her - as these cells have never actually been inside her body.
You first idea was to donate your eggs for the project but the scientists told you this might not only be illegal but also unnecessary. Could you explain why the eggs were unsuitable for the experiment and what the lab used in the end?
In the first instance I was unable to donate an egg because of the birth control I take. I have a three monthly injection (the DEPPO) which works by stopping egg production. It can take a year for your body to start producing eggs again after stopping the DEPPO, so I would not have been able to produce an egg in time for the project.
However, there were also ethical reasons for not donating an egg. I believe fervently in the use of embryos for scientific research, as of course do the scientists I work with. They have to fight for the right to use embryos in their research and under no circumstances would I do anything to jeopardise that. The use of embryos for artistic purposes is a different moral question. I felt that it would have been wrong (and potentially damaging to the scientists working on the project) to confuse those two ethical questions by making an art project utilising the scientific method for making embryonic stem cells.
What we used instead was stem cells derived from adult tissue. These are called Induced Pluripotant Stem Cells (IPSCs) and it is this technology that won the Nobel Prize last year. I donated skin, blood and urine to the lab. The lab was then able (using this new and wonderous technology) to send those cells back to how they were when I was a foetus - to turn them back into the stem cells they had been roughly 29 years ago. You could call it cellular time travel! I find our ability to do this completely awe inspiring.
Now that you've finally met your 'second self, your dopplegänger, do you feel you have some kind of connection to it?
Seeing my heart cells beating was a unique experience - especially the first time I saw it. There is something that feels distinctly 'alive' about the beating heart cells and something quite extraordinary about seeing part of your own heart beating and living outside your body. But in general I would say that I feel no more connected to my second self than I would any other self portrait. I do not feel that these parts of me are sacred in some way, or even that they really belong to me in anything other than the genetic sense. That is really the point of the project - to question how we build our identity as humans and how that might change in the future. This may sound obvious, but I have learnt that I am more than the sum of my parts; that just because something has my heart, my brain and my flowing blood it is not 'me' and it is not a human.
Ergo Sum and the other winning projects of DA4GA are on view until 15 December at Raamsteeg2 in Leiden, in The Netherlands. Ergo Sum is funded by the Netherlands Genomics Initiative.
Adam Brown is a conceptual artist working with scientists to create art pieces that use robotics, molecular chemistry, living systems and emerging technologies. Years ago, i saw one of his works at Emoção Art.ficial [Art.ficial Emotion], a Biennial of Art and Technology in Sao Paulo. The robotic sculpture, called Bion, explored the relationship between humans and artificial life. Fast forward to May 2013 when i am aimlessly clicking around and stumble upon one of his most recent pieces. This time, the project doesn't use swarms of responsive synthetic "life-form" but bacteria that, over a period of one week, process the toxins of gold chloride and produce nuggets of 24-karat gold.
The Great Work of the Metal Lover earned Brown and his collaborator microbiologist Dr. Kazem Kashefi world-wide media coverage, an Honorary Mention at Ars Electronica as well as a Special mention at VIDA.
Brown brings together science and art into each of his works, from the initial concept up to the final realization. His artistic practice not only challenges scientific inquiry but it also comes with undeniable aesthetic qualities (something that is sometimes little more than a second thought in artworks that make use of the latest advances in science and technology.) Simply put, his artworks are beautiful to look at. While the Bion sculpture (below) is as stunning as it is smart, Origins of Life: Experiment #1.x (a working scientific experiment that builds on Miller-Urey's 1953 experiment to draw attention to the artifice and aesthetics of experimentation) neatly hangs scientific instruments and processes on a wall as if they were museum paintings.
Brown is an Associate Professor at Michigan State University where he created the Electronic Art & Intermedia department. He is also a Research Fellow at the Institute for Digital Intermedia Arts at Ball State University, and serves as an Artist in Residence for the Michigan State University BEACON (Bio/Computational Evolution in Action Consortium) project.
I interviewed him via email just before he flew to Sydney to attend the ISEA Symposium on Electronic Art.
Hi Adam! What you've achieved sounds almost like a fantasy... Using bacteria to turn valueless material into gold. I'm sorry for the very mundane question but why don't you make it a full time activity? You could be drinking cocktails on your yacht, on your way to a golf game with Donald Trump instead of answering my questions right now...
This is probably one of the most asked questions that I have received about this piece. The other question that is often asked is if I can share with people how to "make gold." The potential to make gold and accumulate wealth is a very powerful motivator of the human condition. Even Forbes wrote about it. Fortunately, the process is not cost effective at this point. I have to buy the soluble form of gold I put into the reactor and, since the bacteria only grow in anaerobic conditions (no oxygen), I also have large expenses in creating the conditions for their growth.
Of course the natural follow up question is if it is possible to harvest the dissolved concentrations of gold in the oceans (which contain about 10 parts per million). It might be possible, but it would take a great deal of expense to scale up a system that would be efficient and cost effective. However, this is not something that I am interested in doing. What would be the environmental costs of engaging in such an activity? With our limited knowledge of the oceans ecosystem it is unclear what would happen to the ocean life if it were depleted of dissolved gold. As an artist, I'm more concerned with probing and questioning the potential impact of our ability to engineer and control nature.
What brought you to alchemy? A nostalgia for an ancient quest or the mere curiosity to explore what an artist can do with modern microbiology?
Alchemy is a topic that I have been interested in for quite a long time. Alchemy incorporates both a spiritual, creative and scientific pursuit all in one. As an artist of the 21st century working with biological systems, alchemy feels like an appropriate model of reference.
At the height of Alchemy during the time of the European Renaissance the world appeared to be much less defined. Artists were at the same time engineers, architects, alchemists, chemists. It was possible for a single person to strive to be the universal person and have relatively deep knowledge of many fields. Of course times have changed, complexity has grown and specialization has become more necessary. Newer technologies including augmented memory and instantaneous access to information have changed the way artists work. Now instead of being the total person one can employ collaborative practice to venture into territories that were previously inaccessible. This changes the role of the artist to one more akin to manager or director.
I also like the poetics of possibly solving the ancient alchemical problem of the philosopher's stone using modern microbiological science. Interestingly, the process does have some overlap to the description provided by alchemists describing the philosopher's stone. One would know when they were getting close to transmuting base metals into gold because the solution would turn a redish/purple color called "rubedo." The bioreactor of the GWML turns a purplish color when the microbial community is precipitating gold.
You developed the work in collaboration with Kazem Kashefi from the Department of Microbiology and Molecular Genetics at Michigan State University. What form did the collaboration take exactly? Was it you dictating what needs to be done and the scientist was executing your instructions. Or is the experience more hands-on from your part? With a more critical feedback from Dr Kashefi?
The relationship was hands on and mutualistic. One of my major interests is in origins of life research. This led me to extremophiles as they are probably some of the first forms of organized life on the planet and to Dr. Kashefi (Kaz). I read a paper he wrote in 2000 about how anaerobic extremophile microorganisms have the ability to precipitate heavy metals and even gold. I asked him if he thought it possible to devise a system capable of producing enough gold that one could hold in one's hand. This was the beginning of the collaboration. Over the course of a year, Kaz and I conceptualized how to construct a sustained culture capable of this task. He taught me the lab bench practices to, culture, grow anaerobic microorganisms. I designed, conceptualized and built the installation; Kaz led the scientific inquiry but we practiced the science together.
Unlike many works that merge art and science which outcome only appear in art publications, articles about The Great Work of the Metal Lover also appeared in science magazines. So what makes the piece appealing to the scientific community?
One of my goals as an artist, especially when it comes to collaboration is make work that has a high degree of mutuality between the respective disciplines. While it is not always the case, when working collaboratively I like to try to make contributions to the various fields of research that are represented. So, in this case, it is important to not only make contributions to the arts, but also to the sciences. The GWML does tap into interesting science in that we have shown that the microorganism is able to survive and even flourish on much higher concentrations of gold chloride than has ever been reported (ten fold in fact). Secondly, the research is relevant to scientists that are interested in the possibility of metabolic process being responsible for mineral production. Finally, novel uses of microbes, including genetically modified versions, are a hot topic for research at the moment; scientists are looking at biotechnologies to do everything from bioremediation, to microbial pharmaceuticals, to even energy production. Of course, gold does have a universal appeal, having been coveted by most people; scientists are not excluded from this bias.
The artwork doesn't stop at creating gold nuggets, it also features images made using a scanning electron microscope and an ancient gold illumination techniques. Could you explain us what the process involved and what the images represent?
The description of the work Origins of Life: Experiment 1 opens on a quote by biologist E. O. Wilson "The aim of art is not to show how or why an effect is produced (that would be science) but literally to produce it."
The quote illustrates a close alignment between art and science and that the practices are more connected then disconnected. The artist wishes to create a phenomenological output while the scientist's main goal is to understand the phenomenon: a complementary/mutualistic relationship; an epistemological difference signifying that there are many more commonalities than differences. This once again ties into the discussion of the previous question about collaboration and mutualism. Origins of Life is an installation and a performative re-enactment of the Miller experiment that attempts to quite literally depict this relationship. It is in essence a contextual problem filled with an epistemological shifting perspective.
The Great Work can be summed up in a catchy headline, but Origins of Life cannot be reduced so easily to one sentence. Not everyone knows about the Miller-Urey experiment for example. So how do you manage to engage a scientific audience with an artwork and vice versa: how do you get the attention of art lovers with a work that deals with scientific theories?
True. Not everyone knows about the details of the Miller experiment, but big questions such as "where do we come from?" and "how did life begin?" have a much greater universal appeal overlapping with philosophy, religion, art and science. You don't have to know anything about Miller-Urey or theories of how life originated to be fascinated by an apparatus that makes lightning and thunder, bubbles and boils, gleams and glistens and mysteriously converts a tank full of gas into brown-colored goo. Once interested, you can get the scientists to think about the artistic aspects of their practice and the artists to think about creating life as a metaphor for the creative process itself. The origins of life question is also what makes us human.
You also defined the project as being "open source", as it 'invites contributions and participation from other scientists.' If find you very brave. not many artists would be comfortable with the idea. Why was it important to you to leave them this open door instead of keeping the project stable and immutable? Could you tell us how and if scientists have contributed or pushed it further and, more generally, how they have reacted to the work?
Once again, it goes back to the idea of collaborative practice and mutuality and started out as a collaboration with the scientist Robert Root-Bernstein. While it is important for me to have some conceptual ownership over the work, it is also important to attempt to solve the mystery of how life started on the earth. And technically, the original scientific experiment does not belong to me either as it is an appropriation from Miller. Are not the under-pinnings of the scientific method that of "open source"?
I have been interested in the Miller experiment since I was in high school. The original experiment enacted by Miller in 1953 never seemed to make much headway after the initial experiment; that is the production of amino acids from inorganic material. Perhaps this was a result of available technology of the time. When Miller died in 2008 I felt like it was an opportunity to continue with the project. There are many adaptations and further experiments that were never realized or maybe thought of: such as adding a phosphorus source like salt or even running the experiment for longer then a week. Since trying out some of these modifications we have synthesized Adenosine triphosphate (ATP) the power source of cellular life as well as a building block of DNA and also have shown evidence of the production of lipids which are the materials that make up cellular membranes.
Most scientists have been very positive about the project. They realize that scientific funding agencies are very conservative and can only fund what will obviously work. But what we already know will work doesn't help us progress in our understanding. Engaging in the project as a performance lets us break out of the constraints that the scientific peer review system imposes so we can try the kinds of experiments most origins of life scientists would really like to try.
In fact, one scientist who had invented an ultra-sensitive ATP-measuring device, donated one to us so we could test whether we could make ATP along with amino acids. Overall, the scientific community has received the work very positively. Origins of life research in general has massive appeal. It is inspirational to scientists and artists both.
Any upcoming project, exhibition, areas of investigation you'd like to share with us?
I have a few projects in the works. I will definitely share them with you and We-Make-Money-Not-Art when they are ready to be released in the near future.
Yes, please! And thank you for your answers Adam.
The new episode of #A.I.L - artists in laboratories, the weekly radio programme about art and science i present on ResonanceFM, is aired this afternoon at 4pm (London time.)
Today i'm talking with Helen Pynor. You might have seen one of Helen's most striking photos in bookshops and on the tube last year, it showed a brain in all its organic glory and was on the book cover and on the posters advertising the exhibition Brains: The mind as matter, which opened last Spring at the Wellcome Collection in London.
Helen Pynor has a background in science but later studied visual art. Three years ago she also became a doctor of philosophy. Her practice combines biological science and visual expression to explore the inside of our bodies, and to investigate the relationship between the physicality of the human body and its culturally constructed status.
During the show we will be talking about how she managed to get her hands on a fresh human brain but Helen will also discuss some of her broader projects such as The Body Is A Big Place, a large-scale installation that explores organ transplantation and the thresholds between life and death.
Peta Clancy and Helen Pynor (sound by Gail Priest), The Body is a Big Place
It's been too long since i've blogged about a project supported by Symbiotica (although they did get their fair amount of mentions and praises in #A.I.L., the show i present on ResonanceFM.)
For the In-Potentia work, the artists grew cells that were taken from human foreskin cells purchased from an online catalogue. The cells were then re-programmed by genetic manipulation and bio-engineered to become a neural network.
This functioning "brain" is presented in a sculptural incubator containing custom-made automated feeding and waste retrieval system as well as an electrophysiological recording setup.
The work is more clearly explained in the video below:
In-Potentia exposes, in the most limpid and absurd way, how science is blurring what we are used to regard as clear-cut categories, such as where life begins and ends or what constitutes a person. Or in Guy Ben-Ary's words:
What is the potential for artists employing bio-technologies to address, and modify, boundaries surrounding understandings of life, death and person-hood? And what exactly does it mean culturally, artistically, ontologically, philosophically, politically and ethically to make a living biological brain from human foreskin cells?
The artists have kindly accepted to answer my questions:
In Potentia is without doubt a very powerful and thought-provoking work. What is the state of the scientific but also cultural debate around liminal forms of life? where could i read more about it (in a not too daunting, hi-tech language if possible)? do you have simple examples of these 'uncertain lives' at the border between human/non-human, coherent/hybrid, etc.?
Liminal lives can be "brain dead" or coma patients who are only being kept alive due to machinic intervention, or severely pre-term newborns kept alive with external life support systems, or embryos (both within or outside of a female host body) whose status as "pre-beings" disrupts our understanding of "life" as being conscious, independent and "useful". Liminal lives could also be humans with animal (or other human) organ transplants, genetically modified/manipulated (human and non-human) lives that challenge the ontological status of where and how "life" starts, or even non-humans that exhibit "human-like" characteristics of consciousness etc etc. A liminal life can therefore be found anywhere that our traditional western understandings of what it means to be human is challenged, altered or transgressed. If you were only going to read one thing on liminal lives, I would suggest Susan M Squire's 2004 seminal text: Liminal Lives - Imagining the Human at the Frontiers of Biomedicine.
I like the humour behind 'project dickhead' as you nicknamed it but i've been wondering if you're not worried that certain journalists (and bloggers) will jump on the opportunity to depict the project in a simplistic light? Your choice was quite bold because you could have avoided potential simplistic headlines by choosing to use other cells than the ones of foreskin?
Could you briefly explain me the audio-soundscape that exposes the electrical activity of neural signals or synaptic output? It is just the electrical activity from the neural network being amplified? Did you modify the sound in any way to make it more 'evocative' of what the activity of a brain might sound like?
Thanks Guy and Kirsten!
The new episode of #A.I.L - artists in laboratories, the weekly radio programme about art and science i present on ResonanceFM, is aired this afternoon at 4pm (London time.)
Today we will be talking with the flamboyant Adam Zaretsky, a Doctor of Philosophy in Electronic Arts, a researcher and art theorist whose work focuses on Biology and Art Wet Lab Practice. He has been lecturing and doing research in some of the most prestigious institutes around the world. If you've been following this blog for a while you probably know that i LOVE Adam Zaretsky.
Zarestsky has co-habited during one week in a terrarium with E. Coli bacteria, worms, plant, fish, frogs, mice, flies and yeast. He has dedicated part of his research at the Massachusetts Institute of Technology to playing Engelbert Humperdinck's Greatest Hits to fermenting E.Coli continuously for 48 hours and observing the impact that the rather camp music had on the bacteria. More recently, the artist has worked with materials that include surgically manipulated pheasant embryos and a preserved turd of the deceased writer William S. Burroughs.
So that's what we are going to discuss in this episode of #A.I.L., turds from a famous writer but also eyeballs in armpits. And ethics, biotechnological materials and ''Full Breadth Genetic Alterity.
The new episode of #A.I.L - artists in laboratories, the weekly radio programme about art and science i present on ResonanceFM, is aired today at 4pm (London time.)
My guest at Resonance this afternoon is Kira O'Reilly, a performer whose work i've encountered a number of times in biotech art context. I've been particularly drawn to the works that address the ethics of human/animal interactions and more generally our complex relationships with animals. The most discussed of her work is probably inthewrongplaceness, an intimate performance that Kira developed on her return from a residency at the art science collaborative research lab SymbioticA in 2004. Realizing the similarities between the pig's skin and her own, Kira danced skin to skin with a dead pig and invited members of the audience to touch both her own and the skin of the nonhuman animal,
A few years later, Kira presented the performance, Falling Asleep With a Pig in which she cohabited with a live pig called Deliah in a specially constructed sty. Sometimes they shared the space for 36 hours and in other performances, the cohabitation lasted 72 hours.
Kira O'Reilly's work has been exhibited and discussed widely throughout the UK, Europe, Australia, China and Mexico.
Kira is currently busy working on a three year AHRC funded creative fellowship at Queen Mary University of London called Thresholds of Performance, between body, laboratory and text.